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The deep penetrating nevus (dpn), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life.
Van ipenburga conjunctiva caruncle deep penetrating nevus braf β-catenin.
The deep penetrating nevus is characteristically seen in the second to fourth decades of life on the proximal aspect of the upper or lower extremities, the face, or the trunk. Similarities between the plexiform spindle cell nevus and the deep penetrating nevus share the age of the patient, anatomic location, and certain features of the clinical.
Proliferative nodule in melanocytic nevi mimicking deep penetrating nevus. Almodovar-real a(1), molina-leyva a(2), aneiros-fernandez j(3), diaz-martinez ma(1). Author information: (1)department of dermatology, san cecilio university hospital - granada, spain. (2)department of dermatology, torrecárdenas hospital - almería, spain.
21 sep 2017 deep penetrating nevi (dpn) are unusual melanocytic neoplasms with braf: forward 5′-tcataatgcttgctctgatagga-3′; reverse.
Deep penetrating nevus (dpn), also known as a plexiform spindle cell nevus, is a darkly pigmented melanocytic lesion that most often appears as an asymptomatic solitary papule or nodule on the head or neck, trunk, or upper extremities. The dpn is often described by patients as a new or changing lesion, since it is almost always acquired during.
Deep penetrating nevi (dpn) are rare melanocytic nevi, which can exhibit atypical histological features hampering the differentiation from malignant melanoma. Dpn are considered benign melanocytic lesions, but rare spread to lymph nodes and unfavorable clinical outcomes associated with borderline/at.
I would recommend conservative re- i would recommend conservative re- excision given the very close deep margin.
Deep penetrating nevus (dpn) is characterized by enlarged, pigmented melanocytes that extend through the dermis. Dpn can be difficult to distinguish from melanoma but rarely displays aggressive.
We report a clinical and histologic study of 70 patients, each with a single melanocytic lesion termed deep penetrating nevus (dpn).
Deep penetrating nevus (dpn) is a distinct variant of melanocytic nevus and remains a histopathologic challenge to pathologists because of its resemblance to blue nevus, malignant melanoma, pigmented spitz nevus, and congenital melanocytic nevus.
An epithelioid blue nevus is a cutaneous condition most commonly seen in patients with the carney complex. 701; a deep penetrating nevus is a type of benign melanocytic skin tumor characterized, as its name suggests, by penetration into the deep dermis and/or subcutis.
Deep penetrating nevus is a variant of benign pigmented nevi with deep dermal and subcutaneous involvement.
Deep penetrating nevus occurs most commonly over the acral skin of young adults. Clinically, the lesions were diagnosed as pigmented nevus, blue nevus, or malignant melanoma. Histologically, deep penetrating nevus shows a wedge-shaped lesion extending to the deep dermis and the subcutaneous fat tissue.
Plexiform pigmented spindle cell nevus/tumor (deep-penetrating nevus) with atypical features. Melanocytic nevus with phenotypic heterogeneity (combined nevus) with atypical features. This somewhat confusing and archaic term refers to the melanocytes present in melanocytic nevi.
This report describes 41 patients with lesions similar to those previously termed deep penetrating or plexiform spindle cell nevus (dpn). Dpn occurs primarily during the first four decades, is somewhat more common in females, and has a predilection for the face, trunk, and proximal extremities.
In 1989, seab et al 1 described 70 cases of a distinctive melanocytic lesion, for which they coined the term deep penetrating nevus (dpn). Dpn demonstrates a predilection for the face, proximal extremities, and trunk, and typically occurs in the first four decades of life. 1, 2 in most respects, dpn is similar if not identical to a lesion barnhill et al 3 termed “plexiform spindle-cell nevus.
A melanocytic naevus (american spelling ‘nevus’), or mole, is a common benign skin lesion due to a local proliferation of pigment cells (melanocytes). It is sometimes called a naevocytic naevus or just 'naevus' (but note that there are other types of naevi).
Deep penetrating nevi (dpn) are dermal‐based, heavily pigmented melanocytic proliferations primarily resulting from mutations in b‐catenin and braf or, less commonly, nras. Dpns are considered to be intermediate grade tumors which are stable with low risk of malignant transformation.
A deep penetrating nevus (dpn) is an uncommon, benign mole that occurs as a deeply-pigmented skin lesion. When the mole is examined under a microscope by a pathologist, it presents similar features of 2 other nevi - the spitz nevus and blue nevus.
17 jan 2021 deep penetrating nevi (dpn) are dermal‐based, heavily pigmented melanocytic proliferations primarily resulting from mutations in b‐catenin.
The deep penetrating nevus (dpn), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life. Histopathologically, the dpn is wedge-shaped and contains melanocytes that exhibit deep infiltration into the dermis. Given these features, dpn may clinically and histopathologically mimic malignant melanoma, sparking confusion about the appropriate evaluation and management of these lesions.
The cellular blue nevus is a less common lesion but often clinically similar to the common blue nevus. These lesions tend to be large, usually measuring 1-3 cm in diameter.
1 mar 2011 to review clinical and histologic features of deep penetrating nevi and discuss their differential diagnosis, especially regarding melanoma.
Point to remember: deep penetrating nevi are low risk lesions that will ultimately be prognosticated by molecular methods. The deep penetrating nevus j am acad dermatol 2014; 71: 1234-40. Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Differential diagnosis is deep penetrating naevus or blue naevus. Sub 5mm dpn-like but with reverse wedge shape and slightly older age than usual.
Nevus (plural nevi) is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. The term originates from nævus which is latin for birthmark; however, a nevus can be either congenital (present at birth) or acquired.
Context: deep penetrating nevus is a distinctive melanocytic lesion that may simulate melanoma both clinically and histologically. Objective: to review clinical and histologic features of deep penetrating nevi and discuss their differential diagnosis, especially regarding melanoma. Data sources: the literature on deep penetrating nevi is reviewed and supplemented by our experiences with deep penetrating nevi.
Deep penetrating nevus is a distinct form of melanocytic nevus and may mimic various pigmented lesions. This lesion has distinct microscopic features which helps in excluding melanoma and establishing the correct diagnosis.
The deep penetrating nevus is an intradermal or sometimes compound melanocytic neoplasm with three distinctive histological characteristics: — it occupies a large part of the dermis, occasionally reaching the subcutis; — it contains large cells with pale cytoplasm and a variably sized nucleus; — and it has a dark color on clinical examination due to its many melanophages.
A nevus is a benign tumor of the skin or mucosa derived from dermal or submucosal melanocytes. Deep penetrating nevus (dpn) was first mentioned as a distinct entity in 1989, with several cases being initially mistaken as malignant melanoma (mm) and other nevus types. 1 dpn is extremely rare in the oral cavity, with only 1 case reported at the gingiva, 2 despite being most common in the head.
Deep penetrating nevus (dpn) is a distinctive, predominantly intradermal melanocytic nevus, morphologically characterised by a fascicular or plexiform growth of predominantly epithelioid melanocytes with vesicular nuclei, often small eosinophilic nucleoli, pale staining to finely pigmented cytoplasm, and typically accompanied by melanophages.
Dermatology online journal: 3(1): 7 clinical history a 30-year-old man had a raised, bluish lesion on his upper back for an unknown period of time.
Observations: deep penetrating nevus occurs most commonly over the acral skin of young adults. Clinically, the lesions were diagnosed as pigmented nevus, blue nevus, or malignant melanoma. Histologically, deep penetrating nevus shows a wedge-shaped lesion extending to the deep dermis and the subcutaneous fat tissue.
We describe the first presentation of a deep penetrating nevus (dpn) on the ref, reference; seq, sequence; comb, combined; f, forward; r, reverse; cov,.
25 year old man with linear arrangement of multiple deep penetrating nevi (arch dermatol 2003;139:1608) deep penetrating nevus of cheek skin (oral surg oral med oral pathol oral radiol endod 2007;104:e49) unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes (j cutan pathol 2012;39:25).
Background: deep penetrating nevi (dpn) are a relatively uncommon subtype of melanocytic nevi. A small subset of these lesions exhibit atypical features (cytologic and architectural atypia, mitotic activity) seen in melanoma. These lesions we term the deep penetrating nevus-like borderline tumor.
Among them, deep penetrating nevi (dpn) and plexiform nevi have been linked to joint activation of the map kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-catenin and its downstream effector cyclin d1 in these tumors.
Blue naevus (nevus in american spelling) is a type of melanocytic naevus in which spindle-shaped or, less commonly, ovoid naevus cells, are located deep within the dermis.
A melanocytic nevus (also known as nevocytic nevus, nevus-cell nevus and commonly as a mole) is a type of melanocytic tumor that contains nevus cells. Some sources equate the term mole with melanocytic nevus, but there are also sources that equate the term mole with any nevus form.
Deep penetrating nevus (dpn) is a distinctive, predominantly intradermal melanocytic nevus, morphologically characterised by a fascicular or plexiform growth of predominantly epithelioid melanocytes with vesicular nuclei, often small eosinophilic nucleoli, pale staining to finely pigmented cytoplasm, and typically accompanied by melanophages. 1–3 in up to two-thirds of cases, it presents as a combined lesion, usually with a common acquired nevus.
For the deep penetrating nevus group the age range in studies, excluding case report, varied from 3 months to 64 years with a mean age of 30 years, similar to the b-dpn group where the age range was 4–62 years with the mean age in all studies being under 30 years.
Deep penetrating nevus: a case report and brief literature review.
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